PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78
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منابع مشابه
PRDM14 directly interacts with heat shock proteins HSP90α and glucose‐regulated protein 78
PRDM14 is overexpressed in various cancers and can regulate cancer phenotype under certain conditions. Inhibiting PRDM14 expression in breast and pancreatic cancers has been reported to reduce cancer stem-like phenotypes, which are associated with aggressive tumor properties. Therefore, PRDM14 is considered a promising target for cancer therapy. To develop a pharmaceutical treatment, the mechan...
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Heat shock proteins (HSPs) are a family of evolutionary conserved proteins that work as molecular chaperones for cellular proteins essential for cell viability and growth as well as having numerous cyto-protective roles. They are sub-categorised based on their molecular weights; amongst which some of the most extensively studied are the HSP90 and HSP70 families. Important members of these two f...
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ژورنال
عنوان ژورنال: Cancer Science
سال: 2017
ISSN: 1347-9032
DOI: 10.1111/cas.13458